Cochrane Database Syst Rev. Harvard Health Letter. Br J Gen Pract. Article  J Immunol. Impact Factor Calculations In a systematic review and meta-analysis of acupressure for postoperative gastrointestinal symptoms among abdominal surgery patients, Liu et al (2017) stated that “Our results suggested that acupressure might be effective in reducing the incidence of postoperative nausea and vomiting and the need for antiemetic drugs among patients undergoing abdominal surgery. However, to move from association to causation, large-scale, longitudinal studies are necessary to define if and how gut microbiota composition and metabolomic profiles may influence the loss of gluten tolerance and subsequent onset of CD in genetically susceptible subjects. Summary of evidence-based guideline: Complementary and alternative medicine in multiple sclerosis. 2005;579:4851–5. Laboratory tests and biochemical evaluation is crucial in these patients and should be tailored on case-by-case basis. Two investigators independently abstracted study characteristics and assessed study quality, and the investigator group graded the overall strength of evidence using standard criteria. Gut. CD-related antibodies belong to IgA and IgG classes, but only those of IgA class can be regarded as highly sensitive and specific for CD [97]. Dennis J, Cates CJ. More rigorous reporting, including allocation concealment procedure, is needed to strengthen the results”. Gastroenterol Hepatol Bed Bench. The authors concluded that peripheral neuropathy is seen in the majority of patients who receive oxaliplatin. Griffin and colleagues (2018) stated that the use of alternative medicine in chronic rhinosinusitis (CRS) continues to increase in popularity, for the most part without meeting the burden of being based on sound clinical evidence. The first follow-up should include a screening of antinuclear antibodies and non-organ-specific autoantibodies in order to rule out the presence of markers predictive of autoimmune diseases associated with CD. limited applicability to older, chronically ill populations and patients who use cannabis heavily. Saliva samples were collected during late pregnancy and early post-partum. Roshan B, Leffler DA, Jamma S, et al. Huntley A, White A R, Ernst E. Relaxation therapies for asthma: A systematic review. J Pediatr. 1986;292(6519):509-510. Biagi F, Trotta L, Alfano C, et al. 2013;33:1027–30. The International Institute of Bioenergetic Analysis [website]. 1991;144(2):218-221. Cinova J, Palova-Jelinkova L, Smythies LE, et al. Mistletoe in cancer: A systematic review on controlled clinical trials. These patients have traditionally been referred to as non-responsive CD [95, 148]; however, this terminology has resulted in confusion as, in many cases, manifestations are due to associated conditions rather than CD. Clin Epidemiol. In 14 people (mean age of 23.9 years), 49 sports injuries of different kind were treated. The FDA requires manufacturers of FDA-approved products that contain estrogen and progestogen to include a black box warning that reflects the findings of the Women's Health Initiative. Cancer Advisory Panel for Complementary and Alternative Medicine (CAPCAM). Columbia, MD: American Dance Therapy Association; 2004. Studies were identified by a comprehensive search of databases, such as Medline, Embase, and Cochrane Library, up to September 1, 2013. The scientific community has not universally agreed on whether or not a GFD should be prescribed for patients with potential CD. This increased morbidity could be partly due to the late diagnosis of this condition, which on average is around 50 years of age [94]. The actual evidence suggests that a GFD should be recommended only to subjects with symptomatic potential CD. The future opens to new therapeutic and preventive strategies, which are expected to improve the patient’s quality of life and pave the way to a definitive cure for this old disease. Int J Food Sci Nutr. 2002;73(4):367-381. At 8 weeks, the IVMT group experienced significantly improved tender points, pain, depression, and quality of life directly following treatment (all p < or = 0.02), while the placebo group experienced significantly improved tender points only (p < or = 0.05). IgA DGP have been shown to be of little usefulness in diagnosing CD and therefore are not recommended for diagnosis [97]. They stated that in order to confirm its effectiveness, it is necessary to conduct further prospective randomized studies with blinding and evaluate the long-term results. Allentown, PA: NutriWatch; 2003. The authors concluded that overall, there is very limited evidence to support the use of CAM in the treatment of CRS. JAMA. Accessed June 8, 2004. 2015;10(2):e0117146. 2017;66(25);677-678. https://doi.org/10.12688/f1000research.9051.1, https://doi.org/10.1136/gutjnl-2018-317371, http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/, https://doi.org/10.1186/s12916-019-1380-z. Damaged enterocytes express CD71 transporter also on their apical side, resulting in retrotranscytosis of secretory IgA-gliadin complexes (13), thus potentiating gluten trafficking from gut lumen to lamina propria. Farthing MJG, Edwards CRW, Rees LH, Dawson AM. Lammers KM, Khandelwal S, Chaudhry F, et al. Accessed March 8, 2002. Bausewein C, Booth S, Gysels M, Higginson I. Non-pharmacological interventions for breathlessness in advanced stages of malignant and non-malignant diseases. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. CMAJ. Bazzocchi G, Giuberti R. Irrigation, lavage, colonic hydrotherapy: From beauty center to clinic? Leffler DA, Green PH, Fasano A. Extraintestinal manifestations of coeliac disease. Deep oscillation therapy provided very good results in lymph drainage and in other indications. Together with positive anti-tTG and EmA, minimal intestinal lesions indicate potential CD. The authors concluded that the findings suggested that outdoor education and wilderness programs can foster mental health in youths and young adults. Thus, an optimal dose of 0.75 to 1.0 ng/kg ML was given twice a week subcutaneously. PGC-1α was originally discovered as a cold-inducible transcription coactivator of adaptive thermogenesis, a physiological process through which energy is dissipated as heat in response to environmental conditions such as cold stress and overfeeding (8, 51).BAT and skeletal muscle are the two major organs involved in this process. A meta-analysis was performed to evaluate the efficacy and safety of TCM in managing NP and LBP. Jong MC, Lown A, Schats W, et al. 2003;8(3):109-119. The treatment for CD is still primarily a GFD, which requires significant patient education, motivation, and follow-up. Huntley A, Ernst E. Complementary and alternative therapies for treating multiple sclerosis symptoms: A systematic review. Volta U, Molinaro N, De Franceschi L, et al. Anesth Analg. Werkstetter KJ, Korponay-Szabó IR, Popp A, et al. In 2011, the Oslo classification of CD identified the following clinical presentations: classic, non-classic, subclinical, potential and refractory [69]. Clinical and immunological relevance of anti-neuronal antibodies in celiac disease with neurological manifestations. JAMA. In a systematic review and meta-analysis on “Auricular acupressure is an alternative in treating constipation in leukemia patients undergoing chemotherapy”, Jing et al (2019) concluded that “Taken together, as a potential safety therapy, only weak evidence supported the hypothesis that AA (auricular acupressure) effectively prevented constipation in leukemia patients undergoing chemotherapy”. Systematic review and meta-analysis of complementary treatments for women with symptomatic endometriosis. Eastern medicine moves west. 2008;103:2360–5. Kassab S, Cummings M, Berkovitz S, et al. Curr Med Chem. Am J Gastroenterol. 2012;367:2419–26. 2015;7:1565–76. More rarely, intestinal lymphoma may develop from type 1 RCD, with a rate of 14% over 5 years [159]. Lancet. 2015;110:455–61. Compared to lymphomas, small bowel adenocarcinoma is rare, although increasingly detectable in the clinic. } Music therapy for depression. PubMed Central  More research is needed to determine the role of ALF in clinical medicine. Report of the Guideline Development Subcommittee of the American Academy of Neurology. 2007;104(2):290-294. Griffiths et al (1998) examined the the role of the T-lymphocytic cell cycle as well as an autogenous lymphocytic factor (ALF) in the diagnosis and regulation of immunological incompetence. 2014;9:e101249. Furthermore, there also has been no experimental validation of the effectiveness of hypnosis in controlling the symptoms of attention deficit disorder (Baumgartel, 1999). The authors concluded that the cases of sustained long-term remission of metastatic pancreatic cancer are extremely rare. ACG clinical guidelines: diagnosis and management of celiac disease. 2003;(3):CD003150. Osteoporos Int. A total of 315 individuals (chemically sensitive immunocompromised patients, n = 290; controls, n = 25) were investigated. JAMA. CAS  Stamnaes J, Sollid LM. There were no statistically significant differences between groups according to age and body mass index (BMI). This trial (n = 23) was conducted among healthy human research participants experiencing a normal pregnancy. In a systematic review on “Acupressure for respiratory allergic diseases”, Liang et al (2017) concluded that “No reliable conclusions regarding the effects of acupressure on AR (allergic rhinitis) and asthma could be drawn by this review due to the small number of available trials with significant heterogeneity of study design and high/unclear risk of bias. Schencking et al (2012) noted that vitamin C (ascorbic acid) is an immune-relevant micronutrient, which is depleted in viral infections and this deficiency seems to play a critical role in the pathogenesis of herpes infections and in the development of post-herpetic neuralgia (PHN). SIBO small intestinal bacterial overgrowth. 2. Despite the progress made in serology, no antibody test currently available provides a sensitivity and specificity of 100% (Table 3) [96, 97], thus requiring intestinal biopsy as a key adjunct for establishing a correct diagnosis [98]. The final product of this partial digestion is a mix of peptides that can trigger host responses (increased gut permeability and innate and adaptive immune response) that closely resemble those instigated by the exposure to potentially harmful microorganisms [25,26,27,28]. FEBS Lett. Because of the greater risk of developing infections (in some cases lethal or with severe sequelae) from encapsulated bacteria, anti-pneumococcal and anti-meningococcal vaccinations are recommended in this subgroup of patients [106, 107, 152]. Refractory CD is in turn subdivided into two categories, primary and secondary, depending on whether the patients had a symptomatic response since the beginning of GFD, or they had a recurrence of symptoms after a more or less long period of improvement. Shanahan L, McAllister L, Curtin M. Wilderness adventure therapy and cognitive rehabilitation: Joining forces for youth with TBI. 2007;7:8. Academy of Nutrition and Dietetics. Furthermore, hormone therapy does not belong to a class of drugs with an indication for individualized dosing. Clinical symptoms in celiac patients on a gluten-free diet. Sustained partial remission of metastatic pancreatic cancer following systemic chemotherapy with gemcitabine and oxaliplatin plus adjunctive treatment with mistletoe extract. Despite the high prevalence of use, there is still limited information on the types of CAM used in children, particularly for the management of one of the most common childhood health complaints -- acute respiratory tract infection (ARTI). Am Fam Physician. Old and new serological test for celiac disease screening. BMJ Open. Br Med J. The ongoing Celiac Disease Genomic, Environment, Microbiome, and Metabolomic study has been designed to identify potential primary prevention targets by establishing microbiome, metabolomic, and/or environmental factors responsible for loss of gluten tolerance, thus switching genetic predisposition to clinical outcome [186]. 2006;41:408–19. This work was partially supported by the Fondo Incentivazione Ricerca (FIR) to R DeG, Fondi Ateneo per la Ricerca (FAR) to GC and RDe G (from University of Ferrara) and by the National Institute of Health grant R01DK104344 to AF. Alternative medical practices such as chiropractic and homeopathy are becoming increasingly popular in Europe and the United States. statement and Marciniuk DD, Goodridge D, Hernandez P, et al; Canadian Thoracic Society COPD Committee Dyspnea Expert Working Group. Dental Watch. The etiology of CFS remains unclear; however, a number of recent studies have shown oxidative stress may be involved in its pathogenesis. Forschende Komplementarmedizin. J Pediatr Gastroenterol Nutr. padding: 10px; Scand J Gastroenterol. A Canadian Thoracic Society’s clinical practice guideline on “Managing dyspnea in patients with advanced chronic obstructive pulmonary disease” (Marciniuk et al, 2011) stated that “There is insufficient evidence to support the routine use of anxiolytic medications, nebulized opioids, acupuncture, acupressure, distractive auditory stimuli (music), relaxation, handheld fans, counselling programs or psychotherapy”. J Altern Complement Med. The involvement of the paracellular pathway for gluten trafficking in the lamina propria has also been corroborated by genetic studies identifying an association of some tight junction genes with CD [42,43,44]. Egoscue Method. Jelinkova L, Tuckova L, Cinova J, et al. Pharmacological approaches in celiac disease. Lucas S, Leach M, Kumar S. Complementary and alternative medicine utilisation for the management of acute respiratory tract infection in children: A systematic review. Three review authors independently assessed trial quality using the Delphi List and the Cochrane Collaboration's tool for assessing risk of bias. The authors concluded that evidence regarding the safety and efficacy of most CAM methods in GAD is limited. However, a recent phase 2b study by Murray et al. This was a result of methodological differences among the included studies and poor reporting of methodological aspects in most of the included studies. 2018;12(2):78-83. A seronegative CD can be confirmed 1 year after the beginning of a GFD, a convenient time to demonstrate an improvement in both symptoms and histology. Due to the relevant burden induced by gluten withdrawal with consequent worsening of quality of life, about 40% of CD patients are unsatisfied with their alimentary regimen and they would be keen to explore alternative treatments [175]. The review highlighted theoretical and practice similarities between cognitive rehabilitation and WAT, with both proving to be examples of “contextualized intervention”. Accessed June 8, 2004. In a moderate percentage of adult CD patients, a blood smear can detect changes in the membrane and cytoplasm of red blood cells (i.e., Howell–Jolly bodies), whereas pitted red cells can be identified by Nomarski phase contrast microscopy; both these red blood cell abnormalities suggest an underlying hyposplenism [106]. Santiago de Compostela, Spain: Galician Agency for Health Technology Assessment (AVALIA-T); 2006. Di Sabatino A, Brunetti L, Carnevale Maffè G, et al. The effectiveness and tolerability of the homeopathic preparation Spascupreel (SP-11)was compared with that of hyoscine butylbromide treatment in children less than 12 years of age. Serological screening for coeliac disease in vitiligo and alopecia areata. 2011;53:216–8. Onkologie. Hender K. Is Gestalt therapy more effective than other therapeutic approaches? The cytotoxicity induced by CM leads to apoptosis and death of endothelial and tubular cells and may be initiated by cell membrane damage together with ROS and inflammation. Gastrointestinal symptoms in celiac disease patients on a long-term gluten-free diet. Cochrane Database Syst Rev. Hyposplenism as a cause of pneumococcal meningoencephalitis in an adult patient with celiac disease. 2006;(2):CD005476. The total number of patients was 71 in the Pilates group and 68 in the control group. Ozone therapy for the treatment of dental caries. Caio, G., Volta, U., Sapone, A. et al. Traditional Chinese medicine for neck pain and low back pain: A systematic review and meta-analysis. Celiac disease: a comprehensive current review. Outcomes for executive functioning skill development, self-esteem development and quality-of-life post-program should be ascertained to compare with results from adult programs. 2017;24(3):299-307. Outcome measures obtained at baseline and after treatment consisted of Modified Oswestry LBP Disability Index [ODI], Quebec Back Pain Disability Scale [QBPD] and VAS. Studies from our group and others have shown that gliadin can cause an immediate and transient increase in intercellular tight junction permeability of intestinal epithelial cells [23, 24] (Fig. Clin Gastroenterol Hepatol. Fellowes D, Barnes K, Wilkinson S. Aromatherapy and massage for symptom relief in patients with cancer. 2016;151:784–8. text-decoration: line-through; A well-defined follow-up strategy should be agreed by physicians and patients once CD has been diagnosed. A course of treatment may involve 1 or more injections spread over several weeks. Cancer. Links to various non-Aetna sites are provided for your convenience only. Chelation Therapy. The use of alternative medicine by children. The intestinal form of CD is more commonly detected in the pediatric population and children younger than 3 years and is characterized by diarrhea, loss of appetite, abdominal distention, and failure to thrive [71]. A child with refractory coeliac disease. Male gonadal function in coeliac disease: sexual dysfunction, infertility and semen quality. 2006;10(26):1-124. Clin Gastroenterol Hepatol. PubMed Central  2005;65(11):1764-1768. 2015;33(5):353-359. The treatment effects of IVMT persisted at 4 weeks post-intervention for tender points, pain, and quality of life, while placebo effects persisted only for tender points. 1995;40:1902–5. Evaluation was performed by the practitioner based on information given by the patient or care-giver. Allergy. Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease of unknown cause. Direct comparisons of Kava Kava (Piper methysticum) extracts to placebo (4 quality trials, n = 233) were highly heterogeneous. High prevalence of celiac disease in Italian general population. 2013;6:43–52. Barone MV, Troncone R, Auricchio S. Gliadin peptides as triggers of the proliferative and stress/innate immune response of the celiac small intestinal mucosa. Vink AC, Birks JS, Bruinsma MS, Scholten RJPM. 2017;62(1):68-79. Clin Gastroenterol Hepatol. Volta U, De Franceschi L, Lari F, et al. In line with this theory no significant difference in IEL count was observed in mild, partial, and subtotal villous atrophy [130]. Baumgaertel A. As with many other autoimmune diseases, we have witnessed an epidemic of CD, questioning the previous paradigm that gluten is the only key element dictating the onset of the disease in genetically at-risk subjects. Cochrane Database Syst Rev. Nevertheless, new technologies pertinent to human gut biology and immunology are opening unprecedented opportunities for major research breakthroughs. Mode of delivery is not associated with celiac disease. Gluten is the general term for alcohol-soluble proteins present in various cereals, including wheat, rye, barley, spelt, and kamut [1]. Early Warning on New Health Technology. Caio G, De Giorgio R, Volta U. Coeliac disease and dermatitis herpetiformis. Young SM, Gryder LK, Cross C, et al. The disease can occur at any age, with a variety of symptoms/manifestations. 2017;64:286–91. Limited evidence supported the use of Pimpinella anisum and crenotherapy for CRS. CD prevalence is increasing in Western countries. Increased risk of non-alcoholic fatty liver disease after diagnosis of celiac disease. In a review on “The effectiveness of acupuncture, acupressure and chiropractic interventions on treatment of chronic nonspecific low back pain”, Yeganeh et al (2017) concluded that “This systematic review demonstrates that acupuncture, acupressure and chiropractic may have a favorable effect on self-reported pain and functional limitations on NSCLBP. The hygiene hypothesis in autoimmunity: the role of pathogens and commensals. However, the results should be interpreted in the context of the limitations identified, particularly in relation to the heterogeneity in the study characteristics and the low methodological quality in many of the included studies”. Volta U, Tovoli F, Piscaglia M, et al. In practice, however, the overall effectiveness of antioxidants is not known, and the best mixture of agents and dosages is not clear. Accessed September 4, 2003. The research was made on 26 patient aged from 60 to 75 years who were separated into 2 groups: I (n = 13) and II (n = 13). A total of 80 women with peri-menopausal syndrome were recruited and randomized into an intervention group or a control group. Pre-assessment No. Wurn LJ, Wurn BF, King CR, et al. Clinical Chem. J Membr Biol. Topical ozone therapy for the treatment of diabetic leg ulcers. Cochrane Database Syst Rev. Sellitto M, Bai G, Serena G, et al. CAS  Full-text publications (English, German language); CAM versus conventional treatment, placebo/sham or no treatment; GAD diagnosed according to standard criteria; and a validated scale for disease severity were eligible for selection. Clin Chem. It provides very small vertical movements of about 50 micrometers that repeat at a rate of approximately 34 times/second. Martin CS; Workers Compensation Board of British Columbia (WCB) Evidence Based Practice Group. Washington, DC: National Academies Press; 2005. Int J Mol Sci. Markham AW, Wilkinson JM. A systematic review and meta-analysis of acupressure for postoperative gastrointestinal symptoms among abdominal surgery patients. 2013;10:CD001277. Brazzelli M, McKenzie L, Fielding S, et al. The main cause of the pain is continued localized pressure on the surrounding soft tissues. And the scores for vasomotor, psychosocial, and physical domains in the intervention group were significantly lower than those in the control group (p < 0.05). Inclusive medical subject headings and keywords consisted of, but were not limited to, sinusitis and complementary therapies, naturopathy, or traditional Chinese medicine. Lukasiak et al (2013) stated that the so-called "heel spur" is a radiological term referring to adaptive bone growth as a result of chronic over-load enthesopathy of the proximal attachment of the plantar fascia. 2017;184:81–6. 40. Ann Pharmacother. Ottawa, ON: CCOHTA; October 2002. in 2001 and subsequently published in 2010. O'Connor D, Marshall S, Massy-Westropp N. Non-surgical treatment (other than steroid injection) for carpal tunnel syndrome. London, UK: Wessex Institute for Health Research and Development, University of Southampton; 2004;4(1). The following are some of the alternative medicine interventions that Aetna considers medically necessary for properly selected members, subject to applicable benefit plan limitations and exclusions. Cochrane Database Syst Rev. Tosco A, Salvati VM, Auricchio R, et al. Auricular acupressure is an alternative in treating constipation in leukemia patients undergoing chemotherapy: A systematic review and meta-analysis. Safety reporting was poor. A pilot study comparing two manual therapy interventions for carpal tunnel syndrome.  06/17/2020 color: blue!important; 2002;95:79–82. Effects of a carbohydrate supplement upon resting brain activity. Health-related benefits of laughter are mainly reported from spontaneous laughter interventional studies. PubMed  Hormone analyses were conducted on all samples utilizing liquid chromatography-tandem mass spectrometry. Iran J Kidney Dis. Risk of vascular disease in adults with diagnosed coeliac disease: a population-based study. Adv Ther. 2016;36(8):872-878. From 27 chronic pain trials, there was low-strength evidence that cannabis alleviates neuropathic pain but insufficient evidence in other pain populations. Shanahan e al (2009) highlighted the potential application of Wilderness Adventure Therapy (WAT) as a supplementary tool in cognitive rehabilitation with an adolescent traumatic brain injury (TBI) population. They stated that given the study limitations, these findings should be interpreted as preliminary; small, time-related improvements in maternal mood and lower fatigue post-supplementation among placenta group participants may warrant further research. There is a lack of reliable evidence to support the use of insulin potentiation therapy. 8. The current scoping review aims to systematically map the concept, content and outcome of wilderness therapy for childhood cancer survivors. Children with CD should be followed up after 6 months from diagnosis and then every year in order to check symptomatic improvement, adherence to GFD, quality of life, and progressive normalization of CD-related antibodies. Kwon CY, Lee B. Acupuncture or acupressure on Yintang (EX-HN 3) for anxiety: A preliminary review. A critical review of randomized controlled trials of static magnets for pain relief. 2018;11:244–9. The authors concluded that although some interventions such as hot/cold packs, Gua-Sha (scraping therapy), acupuncture, cabbage leaves and proteolytic enzymes may be promising for the treatment of breast engorgement during lactation, there is insufficient evidence from published trials on any intervention to justify widespread implementation. The authors concluded that these results indicated that the recommended daily intake of encapsulated placenta may provide only a modest source of some trace micronutrients and a minimal source of toxic elements.
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